Stabilization of an α-helix by short adjacent accessory foldamers
نویسندگان
چکیده
منابع مشابه
An α‐Helix‐Mimicking 12,13‐Helix: Designed α/β/γ‐Foldamers as Selective Inhibitors of Protein–Protein Interactions
A major current challenge in bioorganic chemistry is the identification of effective mimics of protein secondary structures that act as inhibitors of protein-protein interactions (PPIs). In this work, trans-2-aminocyclobutanecarboxylic acid (tACBC) was used as the key β-amino acid component in the design of α/β/γ-peptides to structurally mimic a native α-helix. Suitably functionalized α/β/γ-pep...
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ژورنال
عنوان ژورنال: Comptes Rendus Chimie
سال: 2016
ISSN: 1631-0748
DOI: 10.1016/j.crci.2015.07.003